Publications
Tissue Exposures to Free and Glucuronidated Monobutylphthalate in Pregnant and Fetal Rats
Clewell RA, Kremer JJ, Williams CC, Campbell JL, Andersen ME, Borghoff SJ. 2008. Tissue Exposures to Free and Glucuronidated Monobutylphthalate in Pregnant and Fetal Rat Following Exposure to di-n-Butylphthalate: Evaluation with a PBPK Model. Toxicol. Sci. 103(2): 241-59.
Furan-Induced Dose Response Relationships for Liver
Moser GJ, Foley J, Burnett M, Goldsworthy TL, Maronpot R. 2008. Furan-Induced Dose Response Relationships for Liver Cytotoxicity, Cell Proliferation, and Tumorigenicity. Exp. Toxicol. Pathol.,
The Environmental Polymorphisms Registry: A DNA Resource to Study Genetic Susceptibility Loci
Chulada PC, Vahdat HL, Sharp RR, DeLozier TC, Watkins PB, Pusek SN, Blackshear PE. 2008. The Environmental Polymorphisms Registry: A DNA Resource to Study Genetic Susceptibility Loci. Hum. Genet. 123(2): 207-14.
Methyl tertiary-butyl ether Mode of Action for Cancer Endpoints in Rodents
George Cruzana, Susan J. Borghoffb, Ann de Peysterc, Gordon C. Hardd, Michael McClaine, Douglas B. McGregorf and Michael G. Thomas. Methyl tertiary-butyl ether Mode of Action for Cancer Endpoints in Rodents.
Characterization of Uterine Granular Cell Tumors in Mice
Veit, A.C., Painter, J.T., Miller, R.A., Hardisty, J.F., and Dixon, D. Characterization of Uterine Granular Cell Tumors in B6C3F1 Mice: A Histomorphologic, Immunohistochemical, and Ultrastructural Study. Vet Pathol, 45: 654-662, 2008.
Subchronic Administration of Indole-3-Carbinol in B6C3F1 Mice and Fischer 344 Rats
Wyde, M.E., Bordelon, N.R., Mann, J., Hill, G., Painter, J.T., Yoshizawa, K., Hebert, C.D., Bucher, J.R., and Nyska, A. Subchronic Administration of Indole-3-Carbinol in B6C3F1 Mice and Fischer 344 Rats Is Associated with Increased Hepatic CYP 1A1 and 1A2 Activities, but without Liver Toxicity. Toxicol Pathol 36(1):168, 2008.
Toxicity and Carcinogenicity Studies of 4-Methylimidazole in F344/N Rats and B6C3F1 Mice
Chan, P.C., Hill, G.D., Kissling, G.E., and Nyska, A. Toxicity and Carcinogenicity Studies of 4-Methylimidazole in F344/N Rats and B6C3F1 Mice. Archives of Toxicology 82(1):45-53, 2008.
Databases Applicable to Quantitative Hazard/Risk Assessment
Waters, MD and Jackson, MA. 2008. Databases Applicable to Quantitative Hazard/Risk Assessment -- Towards a Predictive Systems Toxicology. Toxicol Appl Pharmacol, in press.
Investigation of the Low-Dose Response in In Vivo Induction of Micronuclei and Adducts by Acrylamide
Errol Zeiger, Leslie Recio, Timothy R. Fennell, Joseph K. Haseman, Rodney W. Snyder, and Marvin Friedman (2008) Investigation of the Low-Dose Response in the In Vivo Induction of Micronuclei and Adducts by Acrylamide Toxicological Sciences. Experimental and Toxicologic Pathology.
Genotoxicity of 10 Cigarette Smoke Condensates in Four Test Systems
Demarini DM, Gudi R, Szkudlinska A, Rao M, Recio L, Kehl M, Kirby PE, Polzin G, Richter PA. 2008. Genotoxicity of 10 Cigarette Smoke Condensates in Four Test Systems: Comparisons Between Assays and Condensates. Mutat. Res. 650(1): 15-29.
Comparison of Flow Cytometry and Microscopy-Based Methods for Measuring Micronucleated Reticulocyte
Witt KL, Livanos E, Kissling GE, Torous DK, Caspary W, Tice RR, Recio L. 2008. Comparison of Flow Cytometry and Microscopy-Based Methods for Measuring Micronucleated Reticulocyte Frequencies in Rodents Treated with Nongenotoxic and Genotoxic Chemicals. Mutat. Res. 649(1-2): 101-13.
Bayesian Estimation of Pharmacokinetic and Pharmacodynamic Parameters
Liao, K.H., Tan, Y., Conolly, R.B., Borghoff, S.J., Gargas, M.L., Andersen, M.E., and Clewell, H.J. (2007). Bayesian Estimation of Pharmacokinetic and Pharmacodynamic Parameters in a Mode-of-Action-Based Cancer Risk Assessment for Chloroform. Risk Analysis 27, 1535-1551.
Polyamine-Mediated Regulation of Protein Acetylation in Murine Skin and Tumors
Wei G, Hobbs CA, Defeo K, Hayes CS, Gilmour SK. PMID: 17570504 [PubMed - indexed for MEDLINE] Polyamine-Mediated Regulation of Protein Acetylation in Murine Skin and Tumors.
CEBS—Chemical Effects in Biological Systems: A Public Data Repository
Waters, M., Stasiewicz, S., Merrick, B. A., Tomer, K., Bushel, P., Paules, R., Stegman, N., Nehls, G., Yost, K. J., Johnson, C. H., Gustafson, S. F., Xirasagar, S., Xiao, N., Huang, C. C., Boyer, P., Chan, D. D., Pan, Q., Gong, H., Taylor, J., Choi, D., Rashid, A., Ahmed, A., Howle, R., Selkirk, J., Tennant, R. and Fostel, J. (2008). CEBS--Chemical Effects in Biological Systems: A public Data Repository Integrating Study Design and Toxicity Data with Microarray and Proteomics Data Nucleic Acids Res, 36, D892-900.
Consensus Recommendations to Promote and Advance Predictive Systems Toxicology and Toxicogenomics
Waters, M. and Yauk, C. (2007). Consensus Recommendations to Promote and Advance Predictive Systems Toxicology and Toxicogenomics. Environ Mol Mutagen, 48, 400-3.
Fetal Mouse Phthalate Exposure
Gaido, K.W., Hensley, J.B., Liu, D., Wallace, D.G, Borghoff, S., Johnson, K.J., Hall, S.J., Boekelheide, K. (2007). Fetal Mouse Phthalate Exposure Shows that Gonocyte Multinucleation is Not Associated with Decreased Testicular Testosterone. Toxicol Sciences 97(2):491-503.
14C-Labeled Pulegone and Metabolites Binding to alpha2u-Globulin in Kidneys of Male F-344 Rats
Ferguson, L.J., Lebetkin, E.H., Lih, F.B, Tomer, K.B., Parkinson, H.D., Borghoff, S.J., and Burka, L.T. (2007). 14C-Labeled Pulegone and Metabolites Binding to alpha2u-Globulin in Kidneys of Male F-344 Rats. J Toxicol. Environ. Health A. 70, 1416-1423.
Alpha 2u-globulin Nephropathy and Renal Tumors in National Toxicology Program Studies
Doi, A.M., Hill, G., Seely, J., Hailey, J.R., Kissling, G., and Bucher, J.R. Alpha 2u-globulinNephropathy and Renal Tumors in National Toxicology Program Studies. Toxicologic Pathology 35:533-540, 2007.
Hepatic Transcript Levels for Genes Coding for Enzymes Associated with Xenobiotic Metabolism
Kazuhiko Mori1, Pamela E. Blackshear2, Edward K. Lobenhofer3, Joel S. Parker4, Denise P. Orzech1, Joseph H. Roycroft1, Kimwa L. Walker2, Kennita A. Johnson1, Tiwanda A. Marsh1, Richard D. Irwin1 and Gary A. Boorman1. Hepatic Transcript Levels for Genes Coding for Enzymes Associated with Xenobiotic Metabolism are Altered with Age.
Tip60 Protein Isoforms and Altered Function in Skin and Tumors
Cheryl A. Hobbs, Gang Wei, Karen DeFeo, Barry Paul, Candace S. Hayes and Susan K. Gilmour. Tip60 Protein Isoforms and Altered Function in Skin and Tumors that Overexpress Ornithine Decarboxylase.
Application of Visualization Tools to the Analysis of Histopathological Data
Edward K. Lobenhofer1, Gary A. Boorman3, Kenneth L. Phillips1, Alexandra N. Heinloth2, David E. Malarkey3, Pamela E. Blackshear4, Christopher Houle5 and Patrick Hurban1. Application of Visualization Tools to the Analysis of Histopathological Data Enhances Biological Insight and Interpretation
Heparin and Fibroblast Growth Factors Affect Surfactant Protein Gene Expression in Type II Cells
Leiner KA, Newman D, Li CM, Walsh E, Khosla J, Sannes PL. Heparin and Fibroblast Growth Factors Affect Surfactant Protein Gene Expression in Type II Cells. Department of Molecular Biomedical Sciences, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606, USA.
Genetic Alterations in Cancer Knowledge System: Analysis of Gene Mutations in Mouse and Human Liver
Genetic Alterations in Cancer Knowledge System: Analysis of Gene Mutations in Mouse and Human Liver and Lung Tumors Marcus A. Jackson*, Isabel Lea*, Asif Rashid, Shyamal D. Peddada and June K. Dunnick,1
A New Mouse Model for Carcinogenesis Testing of Medical Implants
Glenda J. Moser, Michael A. Streicker, and William Wustenberg. The rasH2 mouse model can help device manufacturers and FDA make a safe and accurate decision regarding the carcinogenic potential of a device.