Investigative Toxicology
ILS has extensive experience using various genetically modified and conventional mouse models to study a variety of disease conditions. The AAALAC (Association for Assessment and Accreditation of Laboratory Animal Care) accredited animal facilities have separate Specific Pathogen Free (SPF) or non-SPF rooms, where animals from various types of institutions can be accepted. These animals can be bred and maintained or evaluated in various hazard identification assays using ILS' full suite of toxicology services. ILS has experience with over 50 different mouse strains.
Regulatory Testing Services
ILS provides consistent, high quality in-life studies that meet or exceed regulatory requirements.
- OECD/EPA guidelines
- FDA IND (Investigational New Drug) application
- Medical device toxicity and safety testing
- Safety testing for nanomaterials
Research-based Studies
- Mode of action
- Transgenic animal models
- Assay development
- Imaging Studies
Lead Scientist
Susan Borghoff, Ph.D., DABT
Phone: 919 281-1110 Ext. 717
Email: (JavaScript must be enabled to view this email address)
Dr. Borghoff joined ILS in 2006 as the Director of the Investigative Toxicology Division and oversees the Biomarkers and Kinetics program. She is an active member of the Society of Toxicology, and she was an Associate Editor for Toxicological Sciences (2003-2008) and served on the editorial board for Chemical Biological Interactions and Toxicology Letters. She has been a Diplomat of the American Board of Toxicology since 1994. Dr. Borghoff has served on review panels and as a working group member for national and international organizations including USEPA, NIEHS, NCI, IPCS, ECETOC, and IARC. In 1994, Dr. Borghoff received the Frank R. Blood Award for the best paper of the year published in one of the Society of Toxicology research journals. In 2000, she received the Society of Toxicology Risk Assessment Specialty Section Award. Dr. Borghoff has over 20 years of experience in study development, design, and management of in vitro and in vivo toxicological studies; she has a broad knowledge of pharmacokinetics and metabolism of specific chemicals as a step in studying the mode-of-action by which they induce a toxic and/or carcinogenic response. Dr. Borghoff received her Ph.D. and MSPH in Environmental Sciences and Engineering from the University of North Carolina at Chapel Hill.