Information Sciences
ILS' Information Science Program can assist in all stages of data acquisition, management and analysis. Our scientists have extensive experience in toxicology, chemistry, exposure risk assessment, molecular biology, alternative test methods and database development. We provide high level expertise in data procurement and assessment, database design, data management/visualization and scientific writing. Software tools are designed for comparative analysis of data from multiple studies across different endpoints.
Document Preparation
- Draft toxicological reviews of agents that include background information, regulatory standards and toxicological data
- Prepare chemical dossiers that provide concise summaries of toxicological review
- Assist government agencies and other clients with exposure analysis, hazard identification, and risk assessments/safety evaluations
- Provide Comprehensive online literature searches for preparing reviews, dossiers, background documents and databases
- Interpret toxicogenomic and related data for integration with conventional toxicology
- Apply molecular signatures with pathophysiological phenotypes for classifying chemical modes of action
- Identify critical target genes and key events that contribute to specific cancers
- Integrate data for a better understanding of gene-environment interactions in the development of human disease
Database Development
- Design customized databases including tools for data mining, analysis, and visualization
- Customize databases to client specifications for data analysis, entry, annotation and import/export
- Design data mining and query options that generate summaries and displays in tables, charts, graphs, etc.
- Design drill-down functions to view detailed data from individual studies
- Relevant projects have included: NIEHS Genetic Alterations in Cancer (GAC) Database, U.S. EPA/IARC Genetic Activity Profile Database, EPA Inhalation Toxicity Database
- Programming Languages: ASP, C++, CGI, COBOL, ColdFusion, DHTML, EJP, FORTRAN, ISAPI, JAVA, JavaScript, JSP, MFC, MTS, Perl, QBASIC, Servlet, Swing, Visual Basic, and XML
- Development Tools: Rational Rose (OOAD CASE Tool), Developer 2000, ERWin, and VISIO 2000
- Database and Web Servers: Oracle, MS SQL, DB2, DBIV, Access, IIS, Apache, iPlanet, WebSphere, Jrun, Weblogic, .NET, and Site Server Operating Systems: UNIX/LINUX, Os10, Windows XP, and Novell
Geographical Information Systems
- Traditional GIS and mapping services;
- Development of scalable internet mapping;
- Custom programming and GIS application development;
- Database design and management; and
- Geospatial consulting services.
Lead Scientist
Marc Jackson
Phone: 919 544-4589 ext 259
Email: (JavaScript must be enabled to view this email address)
Mr. Jackson has over 28 years of direct experience in the development and management of federal government sponsored scientific databases for the Environmental Protection Agency (EPA) and National Institute of Environmental Health Sciences (NIEHS). Over the past seven years, he has designed and managed the development of NIEHS Genetic Alterations in Cancer (GAC) database. Prior to his role on the GAC database project, Mr. Jackson was responsible for developing and maintaining a database of short-term test results from genotoxicity studies. This database was known as the Genetic Activity Profile database (GAP) and was developed under contract with the U.S. EPA. Mr. Jackson has considerable experience mining both the GAC and GAP databases to study genetic effects induced by different classes of chemicals. In 1976, Mr. Jackson received his B.A. in Biology, from Asbury College.