ILS Information Science Program can assist in all stages of data acquisition, management and analysis. Our scientists have extensive experience in toxicology, chemistry, exposure risk assessment, molecular biology, alternative test methods and database development. We provide high level expertise in data procurement and assessment, database design, data management/visualization and scientific writing. Software tools are designed for comparative analysis of data from multiple studies across different endpoints.
Center for the Evaluation of Alternative Toxicological Methods Link to NICEATM
ILS provides the scientific and administrative support activities for the National Toxicology Program (NTP) Interagency Center for the Evaluation of Alternative Toxicological Methods (NICEATM), which in turn supports the Interagency Coordinating Committee on the Validation of Alternative Methods (ICCVAM). The goal of ICCVAM is to promote the development, validation, acceptance, and use of alternative and revised testing methods and strategies that shall be more predictive of human health and ecological effects than currently available methods and strategies, while replacing, reducing, and refining animal use. ILS provides administrative support for the ICCVAM and its working groups; prescreens methods submitted for consideration by ICCVAM; coordinates the scientific peer review and interagency consideration of new test methods of multi-agency interest; convenes expert workshops to evaluate the validation status of new methods and to identify research and validation studies needed to fill critical knowledge gaps; and disseminates information on the current status of alternative test method development, validation, acceptance, and use. This work has included the creation and support of a website, development of ListServes, and other outreach activities. Report preparation and production are also critical activities on this contract.
- Customize search methods and format reports to match your needs
- Integrate key studies and critical data from disparate sources, including peer-reviewed publications, patents, and unpublished abstracts
- Draft toxicological reviews of agents that include background information, regulatory standards, and toxicological data
- Prepare chemical information reviews that provide concise summaries of toxicological review and comply with regulatory guidelines (e.g., OECD, EFSA)
- Probe the toxicological profile of small molecules and natural products without incurring costs associated with chemical synthesis, wet lab experiments, and animal studies
- Improve understanding of mechanisms of toxicity and structure-activity-relationships
- Prepare chemical dossiers that provide concise summaries of toxicological review
- Assist government agencies and other clients with exposure analysis, hazard identification, and risk assessments/safety evaluations
- Interpret toxicogenomic and related data for integration with conventional toxicology
- Apply molecular signatures with pathophysiological phenotypes for classifying chemical modes of action
- Identify critical target genes and key events that contribute to specific cancers
- Integrate data for a better understanding of gene-environment interactions in the development of human disease
- Edit and review scientific documents to ensure scientific credibility
- Design customized databases including tools for data mining, analysis, and visualization
- Customize databases to client specifications for data analysis, entry, annotation and import/export
- Design data mining and query options that generate summaries and displays in tables, charts, graphs, etc.
- Design drill-down functions to view detailed data from individual studies
- Relevant projects have included: NIEHS Genetic Alterations in Cancer (GAC) Database, U.S. EPA/IARC Genetic Activity Profile Database, EPA Inhalation Toxicity Database
- Development Tools: Rational Rose (OOAD CASE Tool), Developer 2000, ERWin, and VISIO 2000
- Database and Web Servers: Oracle, MS SQL, DB2, DBIV, Access, IIS, Apache, iPlanet, WebSphere, Jrun, Weblogic, .NET, and Site Server Operating Systems: UNIX/LINUX, Os10, Windows XP, and Novell
Geographical Information Systems
- Traditional GIS and mapping services;
- Development of scalable internet mapping;
- Custom programming and GIS application development;
- Database design and management; and
- Geospatial consulting services.
David Allen, Ph.D.
As the VP of Science and Strategy at ILS, Dr. Allen provides scientific leadership, management, and direction to ILS’ programs and core services. He works closely with all scientific staff to support the planning and execution of ILS growth plans, and leads staff planning and employee development. Dr. Allen has over 15 years of experience in regulatory toxicology, test method validation, and in vitro biology. At ILS, Dr. Allen has spent over 8 years providing contract support and leadership for the National Toxicology Program’s Center for the Evaluation of Alternative Toxicological Methods (NICEATM). Prior to joining ILS, he was a toxicologist for the Food and Drug Administration, Center for Drug Evaluation and Research, where he was responsible for evaluating toxicological and pharmacological data for investigational new drug applications. Dr. Allen received his B.S. in Zoology from North Carolina State University, his M.S. in Biological Sciences from the University of North Carolina at Wilmington, and his Ph.D. in Cell Biology also from North Carolina State University.