ILS

Histo-Pathology

A fully equipped state-of-the-art histology department staffed by qualified histotechnologists, offers complete necropsy and histology services including specialized techniques. All services can be performed to GLP guidelines, and materials archived at ILS.

Experienced toxicological and molecular pathologists offer expertise in a wide range of species and study protocols. Our pathologists also consult in academia and industry to provide specialized pathology expertise. We offer experience in the pathology of genetically engineered animal models in both research and regulatory studies. Our scientists have well-recognized expertise and are available to contribute to the study design, implementation, interpretation, and reporting of results.

Histology Services

• Experienced and ASCP Board Certified Histologists
• Full-Screen Rodent Necropsy (onsite and offsite)
• Specialized Necropsies
• TRAMP Prostate Dissection
• Timed Necropsies for RNA Analysis
• Rodent Fetal Dissection
• De-pelting and Total Organ Evisceration (maintaining intact skeleton)
• Perfusion - Hepatic and Full Body
• Full Histological services for Rodent, Human, and Non Mammalian tissues (e.g. Fish and Amphibians)
• Paraffin and Plastic Embedding
• Microtomy - Paraffin, Frozen, and Plastic Sectioning
• Routine Hematoxylin & Eosin Staining
• Special and Immunohistochemical Staining

Pathology Services

• Experienced Board Certified Pathologist on staff
• Toxicologic Pathology
• Gross Necropsy Support
• Evaluation of Transgenic Rodent Models
• Imaging Modalities
• Non-Mammalian Pathology
• Molecular Pathology
• Aperio slide scanning services
• Electronic repository for scanned images
• Pathological evaluation of images
• Facilitation of virtual Pathology working groups
• Integration of in life, gross, molecular, and biochemical endpoints with pathology findings

Lead Scientist

Pamela Blackshear, DVM, Ph.D., DACVP

Dr. Blackshear has 15 years of experience as a researcher and toxicologic pathologist. Dr. Blackshear is currently responsible for overseeing the management, budget, strategic planning, operations, and scientific vision of the Pathology, Histology, and Molecular and Clinical Research Programs at ILS. She has extensive experience evaluating immunohistochemical stains, in situ hybridization, and cell growth evaluation. From 2001-2007, Dr. Blackshear served as the Molecular Biology Program Manager, coordinating and providing oversight for the molecular and cell biology techniques and training and supervising technicians on assays involving nucleic acid isolation that are conducted in the ILS molecular laboratory. Dr. Blackshear obtained her Ph.D. at North Carolina State University and her D.V.M. at Cornell University.