Case Studies2017-12-15T14:35:48+00:00

Case Studies

Safety Assessment of Cosmetic Ingredients

Opportunity: Conduct ingredient safety assessments leveraging next generation tools. Fill data gaps for new ingredients lacking existing literature for assessing safety. Apply next generation approaches appropriately and proficiently to inform on potential safe use of new ingredients. Challenges: Perform systematic review for data and literature [...]

Investigational toxicology – challenging route of administration

Opportunity: Conduct in vivo studies involving submandibular injections of a gel-forming product. Previous efforts by the incumbent CRO had not met client expectations, specifically related to the quality and reproducibility of the results. The client was also confronted with a broad inability among providers to [...]

Literature search to identify toxicity data

Opportunity: Conduct thorough search of publicly available literature to identify data that could impact human health or environmental risk assessments for genetically modified organisms. Submit evaluation results in the proper format and within the time requested. Challenges: Develop evaluation strategy that would meet client expectations. [...]

Interpreting and leveraging Tox21 high-throughput data

Opportunity: Evaluate Tox21 and/or ToxCast high-throughput screening data for food-use chemicals using computational toxicology methods and in-house expertise. Clearly communicate data and analyses in reports and presentations. Identify, highlight, analyze and explain the most important findings from within a broad data set. Challenges: Identify and [...]

Pathological review of genetically modified mouse lung tissue

Opportunity: Thoroughly document and interpret the histopathologic effects resulting from exposure of an emerging occupational hazardous agent in wild type and genetically modified mice, focusing on the potential of the agent to induce both neoplastic and nonneoplastic lesions following long-term exposure. Deliver a clear, concise [...]

RNA extraction from FFPE tumor tissues

Opportunity: Extract RNA from human FFPE tumors to support development of novel chemotherapeutic agents. Accurately and thoroughly identify neoplastic cells in submitted tissue samples to recover sufficient RNA. Challenges: Process a large number of submitted samples with very short lead time. Adhere to extremely tight [...]