Multimedia
HepaRG™ CometChip® Micronucleus Assay as a New Alternative Methodology to In Vivo Genetic Toxicology Testing
ILS Chief Scientific Offier, Les Recio, PhD, DABT shares a presentation of HepaRG™ CometChip Micronucleus Assay as a New Alternative Methodology to In Vivo Genetic Toxicology Testing
A Presentation of the Extended One-Generation Reproductive Toxicity Study (EOGRTS) by Dr. Michelle Creamer-Hente
Toxicology Program Manager & Attending Veterinarian, Dr. Michelle Creamer-Hente, DVM, MS, DACLAM shares a presentation of ILS' Extended One Generation Toxicity Study Capabilities.
ILS Computational Toxicology and Information Sciences Presentation
Principal Data Scientist Shannon Bell, PhD shares a presentation of ILS' Computational Toxicology and Information Sciences services and capabilities.
Case Studies
Safety Assessment of Cosmetic Ingredients
Opportunity: Conduct ingredient safety assessments leveraging next generation tools. Fill data gaps for new ingredients lacking existing literature for assessing safety. Apply next generation approaches appropriately and proficiently to inform on potential safe use of new ingredients. Challenges: Perform systematic review for data and literature [...]
Optimized tissue collection to yield quality RNA for expression profiling
Opportunity: Perform toxicological assessments with cerebral spinal fluid (CSF) collected at termination Challenges: Ensure that RNA from CSF and tissue samples are of high quality and free of hemolysis, and that tissues have an RNA integrity number (RIN) greater than 8.5. Weigh and preserve eight [...]
Investigational toxicology – challenging route of administration
Opportunity: Conduct in vivo studies involving submandibular injections of a gel-forming product. Previous efforts by the incumbent CRO had not met client expectations, specifically related to the quality and reproducibility of the results. The client was also confronted with a broad inability among providers to [...]