Pathology & Histology


ILS offers pathology services to meet the needs of the scientific community and safety testing for regulatory, pre-clinical safety assessment, and research studies with high quality and rapid turnaround.

We provide GLP and non-GLP pathology services, general histopathology evaluation, pathology peer review and pathology working groups, as well as contribute to study design, implementation, interpretation and reporting of results. With our broad toxicology service offering, we also offer specialized, integrated pathology services tailored to your specific research or regulatory objectives.

Our experienced toxicological pathologists have expertise in a wide range of study protocols, species (including genetically engineered animal models) and therapeutic areas. Most of our veterinary pathologists are certified by the American College of Veterinary Pathologists (ACVP) in Anatomic Pathology or both Anatomic and Clinical Pathology.

  • Non-GLP or GLP-compliant histopathological evaluation
  • Molecular biology studies
  • Gross Necropsy Support
  • Evaluation of Transgenic Rodent Models
  • Mammalian and Non-Mammalian Pathology
  • 2-D image analysis
  • Real-time telepathology
  • Pathology peer review services
  • Pathology working groups
  • Immunohistochemical method development and interpretation
  • Integration of in-life, gross pathology, and molecular and biochemical endpoints with pathology findings
  • Interpretation of clinical chemistry results
  • Evaluation and interpretation of cytopathology slides (blood smears, bone marrow, vaginal smears, fluids)
  • Macrodissection – FFPE Tissue
  • Toxicologic Pathology
    • Pre-clinical safety assessment studies
    • Carcinogenicity studies with conventional and genetically-modified species
    • Developmental and Reproductive studies
    • Investigative pathology studies supporting discovery research

Necropsy and Histology

ILS’ state-of-the-art histology laboratory, staffed by experienced and certified histotechnologists, offers complete necropsy and histology services — including specialized techniques.

All services can be performed to GLP guidelines, and materials can be archived at ILS. We offer non-GLP or GLP-compliant, fully integrated in-life studies, necropsy, histology, pathology, toxicogenomics and molecular biology services.

  • Full-screen rodent necropsy (onsite and offsite)
  • Specialized necropsy capabilities, for example:
    • Timed necropsies for RNA analysis
    • TRAMP prostate dissection
    • Rodent fetal dissection
    • De-pelting and total organ evisceration (maintaining intact skeleton)
    • Perfusion — organ or full body

  • Experienced Board-Certified Histologists (American Society for Clinical Pathology)
  • Full histological services for rodent, mammalian, human and non-mammalian tissues
  • Paraffin and plastic embedding
  • Microtomy — paraffin, frozen and plastic sectioning
  • Routine Hematoxylin & Eosin staining and Special staining
  • Immunohistochemical staining